The alcoholic extract of Naravelia zeylanica at 250 and 500 mg/kg doses were tested for anti-allergic activity against passive paw anaphylaxis by measuring paw volume using plethysmograph, mast cell stabilization by ex vivo challenge of antigen in sensitized rat intestinal mesenteries and vascular permeability induced by acetic acid in mice. Dexamethasone, Prednisolone and Indomethacin were used as standard reference drugs. Naravelia zeylanica exhibited significant anti-allergic activity in all above three models and activity was comparable with standard drug. The findings from various studies reveal that the anti-allergic activity of Naravelia zeylanica may be due to the mast cell stabilizing potential, suppression of IgE, and inhibition of release of inflammatory mediators.
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